Journal of cachexia, sarcopenia and muscle · 2025 · 系統性回顧（依標題推測）
Influence of Resistance Training Variables to Improve Muscle Mass Outcomes in Sarcopenia: A Systematic Review With Meta-Regressions.
高齡・肌少・骨骼健康 · 肌少症
中文閱讀摘要
系統性回顧統合分析顯示，阻力訓練對肌少症肌量有顯著但小幅改善，調整訓練變數未帶來更大效益，且年齡為唯一顯著調節變數。
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原始摘要
Background
Resistance training (RT) is the first-line treatment to improve sarcopenia features. However, increasing muscle mass with RT remains challenging and displays inconsistent results. Manipulating training variables may present a novel approach to improve muscle mass gain in sarcopenic individuals. The present study aimed to measure the effectiveness of RT alone on muscle mass outcomes in older adults with sarcopenia and determine the influence of RT variables on muscle mass improvement.
Method
We conducted a systematic review according to PRISMA standards to gather studies that conducted a supervised RT without nutritional intervention in sarcopenia-diagnosed older adults with a muscle mass outcome versus a control group. A search strategy was performed on PubMed, Medline, Cochrane and Google Scholar in the last 14 years, from the publication of the first agreement on the diagnosis (EWGSOP, 2010). Along with sample characteristics, we extracted and analysed the following training variables: frequency (number of sessions per week), intensity (in rating perceived effort and in % of the one repetition maximal load), duration (weeks), volume (number of sets per week), periodization (yes/no) and muscle failure (yes/no). First, we standardized the outcome with Hedge's g and pooled the effect size (ES) of each study in a univariate meta-analysis adjusted for risk of bias. Then, we performed training composition comparisons between 'effective interventions' and 'ineffective interventions', which were previously classified based on the 95% confidence interval (CI) effect size. Finally, relevant variables were regressed as moderators of the weighted ES in a mixed-effects model.
Results
A total of 14 studies representing 528 individuals (73.1 ± 6.6 years, 385 women [73%] and 143 men [27%]) were included for analysis. A significant effect of RT to improve muscle mass was found with a small weighted ES estimate (g = 0.38 [0.18; 0.58] 95% CI, p ≤ 0.001). There was no publication bias across studies (p = 0.7). 'Ineffective interventions' included significantly older individuals (p ≤ 0.01). Training composition was homogenous between the groups. The final model showed that age was the only significant moderator of the ES (estimate = -0.06 [-0.08; -0.03] 95% CI, p ≤ 0.001).
Conclusion
In sarcopenic older adults, designing an evidence-based RT induces significant gains in muscle mass, but training variables manipulation does not yield greater outcomes. This study also unveils that ageing with sarcopenia negatively affects the significant improvement of muscle mass induced by RT.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.1002/jcsm.70162
- PMID／PMCID
- 41365305 / PMC12688407
- 作者
- Delaire L, Courtay-Breuil A, Humblot J, Vidal H, Bonnefoy M, Meugnier E
- 首次發表日期
- 2025-12-01Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 16 ／ 6 ／ e70162
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Delaire L, Courtay-Breuil A, Humblot J, Vidal H, Bonnefoy M, Meugnier E. Influence of Resistance Training Variables to Improve Muscle Mass Outcomes in Sarcopenia: A Systematic Review With Meta-Regressions. Journal of cachexia, sarcopenia and muscle. 2025;16(6):e70162. PMID: 41365305. PMCID: PMC12688407. doi:10.1002/jcsm.70162
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