Journal of foot and ankle research · 2026 · 系統性回顧＋統合分析（依標題推測）
Efficacy and Safety of Dextrose Prolotherapy Versus Corticosteroid Injections in Plantar Fasciitis: A Systematic Review and Meta-Analysis.
踝與足 · 足底筋膜炎
中文閱讀摘要
統合分析顯示，足底筋膜炎短期內皮質類固醇注射止痛優於葡萄糖增生療法，但中期足部功能後者較佳，兩組中期疼痛無差異。
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原始摘要
Background
Plantar fasciitis (PF) is a common cause of heel pain that affects the health-related quality of life of many individuals and has various treatment options. Two effective interventions are corticosteroid (CS) injections and dextrose prolotherapy (DP). This study aimed to compare the efficacy and safety of DP and CS in patients with PF systematically.
Methods
Relevant studies, including those comparing DP and CS for treating PF, were identified by searching electronic databases until August 2025. The visual analog scale (VAS) pain score, foot function index (FFI), and plantar fascia thickness (PFT) were compared between the groups in the short term (0.5-1 month) and mid-term (3 months). Statistical analyses were performed via RevMan 4.5.1, and p < 0.05 was considered statistically significant.
Results
Five RCTs and two cohort studies, with a total of 567 patients, were included in the meta-analysis. The analysis revealed that at the short-term follow-up (1 month), corticosteroid injections were more effective at reducing the VAS pain scores than dextrose prolotherapy for general VAS score (MD = 1.85, 95% CI [0.05, 3.64], p = 0.04), the VAS score at the first step in the morning (MD = 1.26, 95% CI [0.49, 2.02], p = 0.001), and the VAS score for pain while walking (MD = 1.85, 95% CI [0.68, 3.02], p = 0.002). Similarly, at the short-term follow-up (1 month), the analysis revealed a significantly greater reduction in the FFI score (MD = 18.81, 95% CI [0.06, 37.55]) and PFT (MD = 0.26 mm, 95% CI [0.07, 0.45]) in the CS group than in the DP group. At 3 months, the analysis revealed a significant decrease in the FFI score (p = 0.003) in the DP group compared with the CS group, whereas no significant difference was observed in the VAS scores or PFT.
Conclusion
In patients with plantar fasciitis, CS injections had greater efficacy than DP did in the short term; however, their efficacy became similar in the mid-term follow-up, with DP outperforming CS in terms of foot function. Further trials with standardized protocols and long-term follow-ups are needed to address potential biases.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.1002/jfa2.70135
- PMID／PMCID
- 41703400 / PMC12913222
- 作者
- Qafesha RM, Ishreiteh HA, Nassourah AL, Tawil OI, Mashaly D
- 首次發表日期
- 2026-03-01Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 19 ／ 1 ／ e70135
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Qafesha RM, Ishreiteh HA, Nassourah AL, Tawil OI, Mashaly D. Efficacy and Safety of Dextrose Prolotherapy Versus Corticosteroid Injections in Plantar Fasciitis: A Systematic Review and Meta-Analysis. Journal of foot and ankle research. 2026;19(1):e70135. PMID: 41703400. PMCID: PMC12913222. doi:10.1002/jfa2.70135
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