Archives of gerontology and geriatrics · 2026 · 系統性回顧＋統合分析（依標題推測）
Comparative efficacy of combined exercise and nutritional interventions for sarcopenia: A systematic review and network meta-analysis incorporating remote delivery models.
高齡・肌少・骨骼健康 · 肌少症
中文閱讀摘要
統合分析顯示，結合阻力訓練、有氧運動與營養的多模式介入對肌少症效果顯著，但結果受樣本量、年齡及干預時長調節。
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原始摘要
Objective
To identify the most effective interventions to delay the progression of sarcopenia and potentially improve muscle strength and mass, with the ultimate goal of reversing sarcopenia, by comparing all pharmacological and non-pharmacological interventions.
Design
Systematic review and network meta-analysis.
Findings
This analysis identified 115 randomized controlled trials (RCTs) with 10,967 participants which an average age of 74.85 years, together evaluating 27 different interventions. For the primary outcome, endurance training followed by resistance training yielded the highest effect on muscle strength (SMD 2.59, 95% CI 1.50 to 3.69), while general remote training was most effective for lean mass (SMD 1.35, 95% CI 0.41 to 2.29) and physical performance (SMD 2.39, 95% CI 1.26 to 3.53). The combination of nutrition with aerobic and resistance training significantly improved muscle strength (SMD 1.25, 95% CI 0.64 to 1.87) and physical performance (SMD 1.73, 95% CI 1.09 to 2.37). Resistance training significantly improved multiple secondary outcomes: body fat mass (SMD -0.57, 95% CI -0.75 to -0.40), blood inflammatory markers (SMD -1.69, 95% CI -1.95 to -1.43), and knee extension strength (SMD 0.55, 95% CI 0.33 to 0.76). Aerobic exercise reduced body fat (SMD -0.48, 95% CI -0.87 to -0.09) and inflammation (SMD -1.98, 95% CI -2.31 to -1.66), while improving quality of life (SMD 0.71, 95% CI 0.53 to 1.03). Subgroup and meta-regression analyses identified sample size, age, and intervention duration as significant moderators of treatment effects, while sensitivity analyses confirmed the robustness of findings to statistical methods.
Conclusions
This network meta-analysis concludes that applying a multimodal approach involves combining resistance training, aerobic exercise, and targeted nutrition to the sarcopenia population, which will be the most effective strategy for managing sarcopenia. Future efforts should focus on enhancing remote intervention delivery to improve accessibility and adherence among older adults.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.1016/j.archger.2026.106239
- PMID／PMCID
- 41996930
- 作者
- Cao J, Liu Y, Hu J, Zhai T, Pang Z, Li R, Dang F
- 首次發表日期
- 2026-04-08Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 147 ／ 期未提供 ／ 106239
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源尚未確認免費全文。 來源授權標示：cc by。
可回溯引用
Cao J, Liu Y, Hu J, Zhai T, Pang Z, Li R, Dang F. Comparative efficacy of combined exercise and nutritional interventions for sarcopenia: A systematic review and network meta-analysis incorporating remote delivery models. Archives of gerontology and geriatrics. 2026;147:106239. PMID: 41996930. doi:10.1016/j.archger.2026.106239
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