Ageing research reviews · 2026 · 敘述性回顧（依標題推測）
The potential of prehabilitation to enhance recovery in sarcopenic and frail older kidney transplant candidates: A narrative review.
高齡・肌少・骨骼健康 · 肌少症
中文閱讀摘要
敘事性回顧指出肌少症腎移植候選者術後預後差，現有運動預復健證據有限，建議採用個人化多模式介入。
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原始摘要
Background
Older adults represent the fastest-growing segment on kidney transplant (KT) waiting lists. In this population, the high prevalence of sarcopenia and frailty impairs the ability to adapt and respond to metabolic stress, contributing to poorer postoperative outcomes. Given that many adverse events occur in the early postoperative period, the optimal window for intervention is prior to surgery. Prehabilitation, defined as a structured intervention delivered before surgery, aims to enhance postoperative recovery.
Methods
In the context of older adults candidates to KT, we constructed a detailed narrative review on: the development of sarcopenia and frailty as a result of ageing and chronic kidney disease pathophysiologic process; sarcopenia and frail influence on post-operative outcomes, and prehabilitation as a strategy to improve recovery.
Results
Age-related anabolic resistance and hormonal, cellular and metabolic disarrangements resulting from the pathophysiologic process of kidney failure, aggravated by dialysis side effects, result in sarcopenia and frailty. Frail/sarcopenic older adults are more vulnerable to post-operative complications and recovery is prolonged. Published prehabilitation studies for candidates to KT mostly comprised of in-situ exercise-only interventions; prehabilitated patients demonstrated improvement of physical function as compared to baseline and just one study assessed post-operative outcomes. The limited results from these studies reflect the absence of a multimodal approach with a comprehensive and personalized medical, dietetic and psychosocial intervention in addition to exercise, necessary to accomplish success. Based on renal, ageing and surgical scientific literature, a suggested multimodal prehabilitation program is proposed.
Conclusion
Although the optimal structure of prehabilitation remains to be established, individualized multimodal interventions appear to hold promise for optimizing patients during the KT waiting period.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.1016/j.arr.2026.103021
- PMID／PMCID
- 41506605
- 作者
- Tomborelli Bellafronte N, Barril-Cuadrado G, Carli F
- 首次發表日期
- 2026-01-06Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 115 ／ 期未提供 ／ 103021
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源尚未確認免費全文。 來源授權標示：cc by。
可回溯引用
Tomborelli Bellafronte N, Barril-Cuadrado G, Carli F. The potential of prehabilitation to enhance recovery in sarcopenic and frail older kidney transplant candidates: A narrative review. Ageing research reviews. 2026;115:103021. PMID: 41506605. doi:10.1016/j.arr.2026.103021
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