Archives of rehabilitation research and clinical translation · 2026 · 系統性回顧＋統合分析（依標題推測）

Comparative Clinical Effectiveness of Intra-Articular Leukocyte-Rich Platelet-Rich Plasma and Hyaluronic Acid in Treating Knee Osteoarthritis Pain: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

膝 · 膝骨關節炎

中文閱讀摘要

統合分析顯示，膝關節OA患者接受LR-PRP較HA僅在3個月顯著止痛，12個月改善功能與僵硬，但無長期止痛優勢，整體不優於HA。

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原始摘要

Objective

To investigate the clinical effectiveness of intra-articular leukocyte-rich-platelet-rich plasma (LR-PRP) injections versus hyaluronic acid (HA) for pain management in patients with knee osteoarthritis (OA).

Data sources

Four electronic databsases were searched, including PubMed, EMBASE, Scopus, and Web of Science. Studies included in our analysis were published between November 1, 2011, and July 14, 2023.

Study selection

Randomized controlled trials (RCTs) that compared intra-articular LR-PRP versus HA injections in human adults diagnosed with knee OA.

Data extraction

The Cochrane Risk of Bias Tool was used to assess the risk of bias and methodological quality of included RCTs. The mean differences (MDs) and SDs with 95% CIs were used to compare continuous outcomes, using the Review Manager 5.4 software. Two reviewers independently extracted data on patient demographics and study outcome, including Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, Visual Analog Scale scores, and adverse events.

Data synthesis

Nineteen RCTs involving 1771 patients were included. LR-PRP demonstrated significant pain relief compared with HA at 3 months posttreatment, but not at 1, 6, or 12 months. At 12 months, LR-PRP was associated with improved WOMAC physical function (MD=-6.37; 95% CI, -12.51 to -0.24; I ²=85%) and stiffness scores (MD=-0.63; 95% CI, -0.98 to -0.27; I ²=0%), but no differences were observed at earlier timepoints or in total WOMAC scores. Adverse event rates were similar between groups.

Conclusions

LR-PRP provides long-term functional improvements in patients with chronic knee OA, though evidence for short-term functional benefits remains limited. LR-PRP shows no long-term advantage over intra-articular HA injections in pain relief. Overall, the evidence does not support the superiority of LR-PRP over HA in managing knee OA.

至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19

書目、來源與全文狀態

DOI: 10.1016/j.arrct.2025.100573
PMID／PMCID: 42326600 / PMC13282763
作者: Peng YN, Huang D, Chou IL, Lew HL
首次發表日期: 2026-01-28Europe PMC 提供，部分日期可能依年份或月份推定。
卷／期／頁碼或文章編號: 8 ／ 2 ／ 100573
書目來源與查核日期: Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
全文與授權: 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。來源授權標示：cc by。

可回溯引用

Peng YN, Huang D, Chou IL, Lew HL. Comparative Clinical Effectiveness of Intra-Articular Leukocyte-Rich Platelet-Rich Plasma and Hyaluronic Acid in Treating Knee Osteoarthritis Pain: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. Archives of rehabilitation research and clinical translation. 2026;8(2):100573. PMID: 42326600. PMCID: PMC13282763. doi:10.1016/j.arrct.2025.100573

原始文獻 ↗來源列出的免費全文 ↗

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