The journal of nutrition, health & aging · 2025 · 系統性回顧＋統合分析（依標題推測）
Comparative Effectiveness of Exercise and Protein-Based Interventions on Muscle Strength, Mass, and Function in Sarcopenia: A Systematic Review and Network Meta-Analysis.
高齡・肌少・骨骼健康 · 肌少症
中文閱讀摘要
系統性回顧與網路統合分析顯示，阻力與平衡訓練結合蛋白質補充對肌少症患者肌力、質量及功能改善效果顯著。
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原始摘要
Background
Exercise, protein supplementation, and their combination are guideline-recommended strategies for managing sarcopenia. This study aimed to compare the effectiveness of various types of voluntary and simulated exercise on the outcomes of muscle strength, physical function, and muscle mass in individuals with sarcopenia.
Methods
We systematically searched PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials through December 2024 and conducted a frequentist random-effects network meta-analysis. The certainty of evidence was assessed using the GRADE framework, and interventions were categorized according to their relative effectiveness and certainty ratings.
Results
A total of 96 eligible studies involving 7,596 participants were included. Resistance and balance training combined with protein-based nutritional supplementation (RBT + Nu) was the most effective intervention for improving grip strength (MD = 5.45 kg, 95% CI: 3.58-7.33), gait speed (MD = 0.20 m/s, 95% CI: 0.11 to 0.29), SPPB (MD = 3.59 points, 95% CI: 1.91-5.27), and skeletal muscle index (MD = 0.95 kg/m², 95% CI: 0.16-1.74). Improvements in gait speed and SPPB exceeded the minimal clinically important difference, while gains in grip strength were potentially clinically meaningful. Resistance and balance training (RBT) achieved the most significant improvement in the timed up and go test (MD = -2.29 s, 95% CI: -3.16 to -1.41), whereas aerobic and resistance training combined with nutrition was most effective in the five-times sit-to-stand test (MD = -2.86 s, 95% CI: -4.55 to -1.17); both improvements are potentially clinically meaningful. Resistance training with nutrition showed the largest improvements in knee extension strength (SMD = 0.98, 95% CI: 0.63-1.33) and appendicular skeletal muscle mass (MD = 0.33 kg/m², 95% CI: 0.27 to 0.38). Aerobic, resistance, and balance training produced the greatest benefit for balance performance (SMD = 0.73, 95% CI: 0.13-1.34).
Conclusion
High-certainty evidence supports RBT + Nu as the most effective intervention for improving muscle strength, muscle mass, and physical function in individuals with sarcopenia. We recommend combining RBT with protein and amino acid supplementation as an optimal strategy when feasible.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.1016/j.jnha.2025.100718
- PMID／PMCID
- 41205420 / PMC12639618
- 作者
- Yan R, Jia S, Lu D, Song W, Zhang W, Sun J, Li D
- 首次發表日期
- 2025-11-09Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 29 ／ 12 ／ 100718
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Yan R, Jia S, Lu D, Song W, Zhang W, Sun J, Li D. Comparative Effectiveness of Exercise and Protein-Based Interventions on Muscle Strength, Mass, and Function in Sarcopenia: A Systematic Review and Network Meta-Analysis. The journal of nutrition, health & aging. 2025;29(12):100718. PMID: 41205420. PMCID: PMC12639618. doi:10.1016/j.jnha.2025.100718
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