Kidney medicine · 2026 · 系統性回顧＋統合分析（依標題推測）
Efficacy of Neuromuscular Electrical Stimulation in Patients on Hemodialysis: An Updated Systematic Review and Meta-analysis.
心血管・呼吸・內科 · 慢性腎臟病
中文閱讀摘要
統合分析顯示，血液透析患者使用NMES可顯著提升下肢肌力與功能，但未改善肌量與生活品質，且證據確信度有限。
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原始摘要
Rationale & objective
Kidney disease is associated with reduced physical function, muscle mass, and quality of life (QoL). Neuromuscular electrical stimulation (NMES) is a promising intervention to address these outcomes. This study aimed to update previous meta-analyses by including the latest randomized controlled trials (RCTs).
Study design
Systematic review and meta-analysis of RCTs.
Setting & study populations
RCTs evaluating effects of NMES in adult patients with kidney disease.
Selection criteria for studies
Outcomes included muscle strength, muscle mass, functional capacity, physical performance, activities of daily living, physical activity, health-related QoL, and adverse events.
Data extraction
A systematic search was conducted in PubMed, Cochrane Library, and ICHUSHI (April 27, 2024).
Analytical approach
Random-effects meta-analyses were performed using Review Manager 5.4. Risk of bias and certainty of evidence were assessed using RoB 2.0 and GRADE.
Results
Twelve RCTs involving 289 participants were included. All participants underwent hemodialysis; no studies included patients on peritoneal dialysis, with predialysis chronic kidney disease, or post-kidney transplant recipients. NMES significantly improved lower-limb muscle strength (standardized mean difference, 0.84; 95% CI, 0.56-1.11; P < 0.001), 6-minute walk distance (mean difference, 48.15; 95% CI, 15.86-80.44; P = 0.003), and sit-to-stand performance (standardized mean difference, 0.80; 95% CI, 0.17-1.43; P = 0.01), without significantly increasing adverse events. No significant effects were found on appendicular skeletal muscle mass, timed up and go test, Short Physical Performance Battery, activities of daily living, physical activity, or HRQoL. The certainty of evidence ranged from very low to moderate across outcomes.
Limitations
Most studies had small sample sizes and high risk of bias.
Conclusions
NMES is a safe and effective intradialytic intervention for improving lower-limb muscle strength and functional capacity in patients undergoing hemodialysis. High-quality RCTs involving broader kidney disease populations are warranted to further establish its clinical utility.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.1016/j.xkme.2026.101368
- PMID／PMCID
- 42222442 / PMC13218137
- 作者
- Otobe Y, Usui N, Kojima S, Shirai N, Suzuki Y, Kono K, Yabe H, Matsufuji S, Sofue T, Fujii N, Narita I, Yamagata K, Hoshino J, Matsuzawa R, Saitoh M
- 首次發表日期
- 2026-04-16Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 8 ／ 6 ／ 101368
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Otobe Y, Usui N, Kojima S, Shirai N, Suzuki Y, Kono K, Yabe H, Matsufuji S, Sofue T, Fujii N, Narita I, Yamagata K, Hoshino J, Matsuzawa R, Saitoh M. Efficacy of Neuromuscular Electrical Stimulation in Patients on Hemodialysis: An Updated Systematic Review and Meta-analysis. Kidney medicine. 2026;8(6):101368. PMID: 42222442. PMCID: PMC13218137. doi:10.1016/j.xkme.2026.101368
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