Seminars in nuclear medicine · 2026 · 敘述性回顧（依標題推測）
The evolving role of nuclear medicine in osteomyelitis: A narrative review of current evidence and future horizons.
其他（運動科學・政策・牙科等） · 骨髓炎
中文閱讀摘要
本敘事性回顧指出，核醫學診斷骨髓炎時，WBC顯像與FDG PET/CT具高準確性，但後者易受無菌性發炎干擾，未來發展聚焦於病原體特異性分子診斷。
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原始摘要
Objective
The diagnosis of osteomyelitis (OM) remains a significant clinical challenge, often requiring a multimodality imaging approach to differentiate infection from non-infectious inflammatory conditions. This review focuses on primary and secondary osteomyelitis, with particular emphasis on fracture-related infections, sternal infections, and the assessment of dissemination of infection using nuclear medicine techniques, from established scintigraphic methods to advanced hybrid imaging and emerging technologies.
Findings
While three-phase bone scintigraphy remains a highly sensitive initial screening tool, its utility is limited by low specificity. White blood cell (WBC) scintigraphy, particularly when combined with SPECT/CT offers superior specificity and is considered a cornerstone for diagnosing musculoskeletal infections. ¹⁸F-FDG PET/CT has emerged as a powerful modality with high diagnostic accuracy, especially for evaluating fracture-related infections or dissemination of infection. However, its performance can be confounded by sterile postsurgical inflammation, though specific uptake patterns and a high negative predictive value are clinically valuable. Emerging frontiers, including dynamic PET acquisition, AI-driven image enhancement, and novel pathogen-specific radiotracers, promise to overcome current limitations by improving specificity and providing biologically targeted information.
Conclusion
The integration of scintigraphic and hybrid imaging techniques, tailored to the specific clinical scenario, is paramount for the accurate diagnosis of OM. Future developments are rapidly moving the field from non-specific inflammation imaging toward precise, pathogen-targeted molecular diagnostics.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.1053/j.semnuclmed.2026.03.002
- PMID／PMCID
- 41916841
- 作者
- Gatón-Ramírez J, Slart RHJA, Gheysens O, Noriega-Álvarez E, Glaudemans AWJM
- 首次發表日期
- 2026-03-30Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 56 ／ 3 ／ 442-451
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源尚未確認免費全文。 來源授權標示：cc by。
可回溯引用
Gatón-Ramírez J, Slart RHJA, Gheysens O, Noriega-Álvarez E, Glaudemans AWJM. The evolving role of nuclear medicine in osteomyelitis: A narrative review of current evidence and future horizons. Seminars in nuclear medicine. 2026;56(3):442-451. PMID: 41916841. doi:10.1053/j.semnuclmed.2026.03.002
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