The American journal of sports medicine · 2026 · 系統性回顧（依標題推測）

Fibrin-Based Scaffold Augmentation During Meniscal Repair May Enhance Healing and Functional Outcomes: A Systematic Review

膝 · 半月板撕裂

中文閱讀摘要

系統性回顧顯示，月狀軟骨修復輔以纖維蛋白支架可提升癒合率與功能分數，但各方法結果不一，證據等級四。

AI 依來源摘要整理，未經人工逐篇核對。閱讀結論前，請回溯研究族群、方法與限制。

原始摘要

Background

Biologic augmentation techniques, such as fibrin-based scaffolds, have been proposed to enhance healing of meniscal tears, particularly in avascular zones. However, clinical outcomes remain variably reported.

Study design

Systematic review; Level of evidence, 4.

Purpose

To evaluate the healing rate, complication rate, and patient-reported outcome scores after meniscal repair augmented with fibrin-based scaffolds.

Methods

A systematic review was conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, searching PubMed, Embase, and Ovid MEDLINE through October 15, 2025. Studies evaluating fibrin-based augmentation during meniscal repair were included. Primary outcomes were healing and complication rates. Secondary outcomes included International Knee Documentation Committee (IKDC), Lysholm, and Tegner scores.

Results

Of 757 studies, 15 met inclusion criteria, comprising 438 patients with meniscal tears in mostly avascular zones. Of these, 345 underwent fibrin-based augmentation; the rest did not. There were 4 fibrin-based methods identified: fibrin clot from peripheral venous blood (FC-PVB; n = 252), fibrin clot from bone marrow aspirate concentrate (FC-BMAC; n = 30), platelet-rich fibrin (PRF; n = 15), and PRF combined with platelet-rich plasma (PRF+PRP; n = 48). Among patients who received FC-PVB, 77.5% achieved complete healing, 12.2% partial healing, and 10.3% failure. Complications occurred in 8.2% of patients who received FC-PVB and included paresthesia and reinjuries; 2.6% reported persistent knee pain. In FC-PVB studies, significant improvements were seen in IKDC and Lysholm scores but not in Tegner scores. Other fibrin-based methods showed consistent improvements across all scores. Compared to nonaugmented repair, fibrin-based augmentation yielded superior outcomes.

Conclusion

Fibrin-based augmentation demonstrated high healing rates, low complication rates, and improved clinical outcome scores. Compared to nonaugmented repair, fibrin-based scaffolds achieved better healing and function. FC-PVB enhanced symptom relief and functional recovery, while only FC-BMAC showed improvements in activity levels.

至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19

書目、來源與全文狀態

DOI: 10.1177/03635465261440395
PMID／PMCID: 42233488 / PMC13620251
作者: Skaik K, Kahlon H, Bouchard MD, Vivekanantha P, Belzile EL, Matache BA, Abouali J
首次發表日期: 2026-06-03Europe PMC 提供，部分日期可能依年份或月份推定。
卷／期／頁碼或文章編號: 54 ／ 12 ／ 3081-3092
書目來源與查核日期: Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
全文與授權: 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。來源授權標示：cc by。

可回溯引用

Skaik K, Kahlon H, Bouchard MD, Vivekanantha P, Belzile EL, Matache BA, Abouali J. Fibrin-Based Scaffold Augmentation During Meniscal Repair May Enhance Healing and Functional Outcomes: A Systematic Review. The American journal of sports medicine. 2026;54(12):3081-3092. PMID: 42233488. PMCID: PMC13620251. doi:10.1177/03635465261440395

原始文獻 ↗來源列出的免費全文 ↗

本站供教育與研究參考。單篇摘要、文體標籤與期刊影響係數不等於證據品質或個別病人的診療建議。