Orthopaedic journal of sports medicine · 2026 · 系統性回顧＋統合分析（依標題推測）
Comparing the Efficacy and Safety of Intra-articular Injection Treatments for Hip Osteoarthritis: A Systematic Review and Network Meta-analysis
髖與鼠蹊 · 髖關節骨關節炎
中文閱讀摘要
針對髖關節骨關節炎，系統性回顧與網路統合分析比較八種關節內注射，結果顯示各注射類型在3、6、12個月對WOMAC及VAS改善無顯著差異。
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原始摘要
Background
Hip osteoarthritis is a debilitating condition that leads to progressive joint pain and stiffness. While total hip arthroplasty provides definitive treatment, intra-articular injections offer a less invasive alternative for patients. Several injection options are available, including corticosteroids (CS), hyaluronic acid (HA), and platelet-rich plasma (PRP). Previous reviews and network meta-analyses have compared the short-term efficacy of these injections, but it remains unclear if a particular injection provides superior symptom relief for up to 12 months.
Purpose
To provide an updated summary of the current hip intra-articular injection literature and compare the efficacy of all injection types at 3 months, 6 months, and 12 months.
Study design
Systematic review; Level of evidence, 1.
Methods
Four databases were queried: Web of Science, Embase, MEDLINE, and Cochrane Central Register of Controlled Trials. The primary outcome measures were the Western Ontario and McMaster Universities Osteoarthritis Index Total Score (WOMAC-Total) and the visual analog scale (VAS) at 3, 6, and 12 months. The Cochrane risk-of-bias tool was used to assess study quality. Treatment effects were expressed as mean differences for the WOMAC-Total and standardized mean differences for the VAS.
Results
A total of 14 studies were included in the final analysis with 1254 participants. Eight unique intra-articular injection types were identified: CS, HA of varying molecular weights (low, high, and ultra-high), PRP, CS + high molecular weight HA, PRP + HA, and standard of care/placebo (SOC/PBO) group. When compared with SOC/PBO, no statistically significant differences in WOMAC-Total and VAS outcomes were observed between any injections at 3, 6, or 12 months.
Conclusion
There were no statistically significant differences in WOMAC-Total and VAS outcomes at any time point between all injection types to baseline. Future studies should compare the long-term efficacy of various intra-articular injections with a control and examine the efficacy of combined injections.
Registration
CRD42024574937 (PROSPERO identifier).
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.1177/23259671261419519
- PMID／PMCID
- 41993104 / PMC13080160
- 作者
- Liu C, Deng J, Abbas A, Lameire DL, Abdel Khalik H, Whelan D, Dwyer T, Chahal J
- 首次發表日期
- 2026-04-13Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 14 ／ 4 ／ 23259671261419519
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Liu C, Deng J, Abbas A, Lameire DL, Abdel Khalik H, Whelan D, Dwyer T, Chahal J. Comparing the Efficacy and Safety of Intra-articular Injection Treatments for Hip Osteoarthritis: A Systematic Review and Network Meta-analysis. Orthopaedic journal of sports medicine. 2026;14(4):23259671261419519. PMID: 41993104. PMCID: PMC13080160. doi:10.1177/23259671261419519
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