PloS one · 2026 · 範疇回顧（依標題推測）
Platelet-rich plasma for immature post-traumatic scars and early keloids: A scoping review.
注射・再生・儀器治療 · 富血小板血漿治療
中文閱讀摘要
PRP治療未成熟創傷疤痕及早期疤痕疙瘩之範圍式回顧顯示，初步證據提示可能改善疤痕分數且無嚴重不良事件，但證據極有限且異質性高，不足以支持常規預防使用。
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原始摘要
Background
Post-traumatic cutaneous scars enter an immature phase after re-epithelialization, characterized by ongoing inflammation and active remodeling. This phase, typically within six months of injury, may allow preventive interventions before pathological scarring develops. Platelet-rich plasma (PRP) has been suggested as a modulator of scar remodeling due to its growth factor content, but its role in immature scars has not been systematically reviewed.
Objective
To map and summarize the clinical evidence on autologous platelet-containing plasma (ACP), including platelet-rich plasma (PRP), for immature post-traumatic scars and early keloids, and to identify gaps for future research.
Methods
A scoping review was performed following established frameworks and reporting guidelines. Databases including PubMed/MEDLINE, DOAJ, SciELO, LILACS, and Google Scholar were searched. Studies evaluating ACP or PRP applied to post-traumatic scars within six months post-epithelialization were included.
Results
Five studies involving 65 patients met inclusion criteria, including randomized trials, observational studies, and case reports. PRP was mainly delivered via intralesional injection. Evidence suggests PRP may improve clinical scar scores and patient-reported outcomes, with no serious adverse events reported. However, studies were heterogeneous in PRP preparation, dosing, timing, and outcome measures. No study was designed to assess PRP as a preventive monotherapy.
Conclusions
Evidence for PRP in immature post-traumatic scars and early keloids is extremely limited and heterogeneous. While preliminary findings indicate potential benefit and safety, current data are insufficient to support routine preventive use. High-quality, prospective studies are needed to determine whether PRP can influence scar remodeling or prevent pathological scarring.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.1371/journal.pone.0345754
- PMID／PMCID
- 41941458 / PMC13052873
- 作者
- Blandón V, Alvarado A, Borge M, Correa E, Leyton T, Gonzalez S
- 首次發表日期
- 2026-04-06Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 21 ／ 4 ／ e0345754
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Blandón V, Alvarado A, Borge M, Correa E, Leyton T, Gonzalez S. Platelet-rich plasma for immature post-traumatic scars and early keloids: A scoping review. PloS one. 2026;21(4):e0345754. PMID: 41941458. PMCID: PMC13052873. doi:10.1371/journal.pone.0345754
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