Sao Paulo medical journal = Revista paulista de medicina · 2026 · 系統性回顧＋統合分析（依標題推測）
Synovitis detection in rheumatology: a systematic review and meta-analysis of contrast-enhanced ultrasound and magnetic resonance imaging.
全身性肌肉骨骼・風濕・疼痛 · 滑膜炎
中文閱讀摘要
系統性回顧顯示對比增強超音波與MRI診斷滑膜炎準確度相近，但RA患者MRI偵測率較高，因研究數量有限，結果泛化性受限。
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原始摘要
Background
Synovial tissue proliferation in the bare area of the joint is an early indicator of synovitis. Vascularization of the pannus helps differentiate between inactive and inflammatory processes, directly impacting therapeutic management. Synovitis can be diagnosed through clinical assessment, ultrasound, and magnetic resonance imaging (MRI); however, uncertainty remains regarding the optimal imaging modality.
Objective
This study aimed to determine the accuracy of ultrasonography with microbubble contrast and contrast-enhanced MRI in diagnosing synovitis, irrespective of its etiology. In addition, the study aimed to determine the joints that were most accurately assessed for synovitis using microbubble ultrasound.
Methods
Electronic searches were conducted in the Cochrane Library, MEDLINE, EMBASE, LILACS, SCOPUS, CINAHL, and Web of Science up to February 8, 2025, with additional screening of reference lists. Studies assessing diagnostic accuracy or detection rates of contrast-enhanced ultrasound (CEUS) and contrast-enhanced MRI for synovitis were included without restrictions on language or publication status. Two studies were selected after quality assessment using QUADAS-2, and eight studies were assessed using the RTI item bank methodology.
Results
Diagnostic accuracies of contrast-enhanced ultrasonography (87%) and contrast-enhanced MRI (87.7%) were comparable. For knee evaluation, CEUS showed a higher detection rate (93.8%) than MRI (82.9%). Across different joints and underlying diseases, the detection rates were 81.9% and 88.3% for contrast-enhanced MRI. In patients with rheumatoid arthritis, MRI demonstrated a higher detection rate (96.2%) compared with ultrasound (67.2%). These findings indicate a similar overall diagnostic performance, although the limited number of included studies restricted generalizability.
Conclusion
CEUS demonstrated diagnostic accuracy comparable to contrast-enhanced MRI, except in patients with rheumatoid arthritis. Given its low cost, portability, and favorable safety profile, CEUS may serve as a useful screening or follow-up tool for synovitis, pending validation in larger multicenter studies.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.1590/1516-3180.2025.3088.11112025
- PMID／PMCID
- 41983885 / PMC13075972
- 作者
- Abreu BFBB, Scarmagnan GS, Duarte ML, Silva MOD, Iared W
- 首次發表日期
- 2026-04-10Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 144 ／ 2 ／ e20253088
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Abreu BFBB, Scarmagnan GS, Duarte ML, Silva MOD, Iared W. Synovitis detection in rheumatology: a systematic review and meta-analysis of contrast-enhanced ultrasound and magnetic resonance imaging. Sao Paulo medical journal = Revista paulista de medicina. 2026;144(2):e20253088. PMID: 41983885. PMCID: PMC13075972. doi:10.1590/1516-3180.2025.3088.11112025
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