Frontiers in bioengineering and biotechnology · 2025 · 統合分析（依標題推測）
Platelet-rich plasma in arthroscopic rotator cuff repair: a meta-analysis of biomaterial efficacy and future directions for personalized sports medicine.
肩 · 旋轉肌袖撕裂
中文閱讀摘要
統合分析顯示PRP輔助肩袖修復可改善功能分數與疼痛，但未顯著降低再撕裂率，且大撕裂及去白細胞PRP效果較佳。
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原始摘要
Background
Rotator cuff tears represent a prevalent musculoskeletal challenge with high postoperative retear rates despite surgical advances. Platelet-rich plasma (PRP) has emerged as a promising biological adjunct in arthroscopic repair, though clinical evidence remains inconsistent regarding its efficacy in improving structural and functional outcomes.
Methods
This PRISMA-guided meta-analysis evaluated 13 randomized controlled trials (n = 880 patients) comparing PRP-augmented versus conventional arthroscopic rotator cuff repair. Primary outcomes included retear rates and functional scores (UCLA, Constant, SST, ASES, VAS). Statistical analysis employed fixed/random-effects models with subgroup analyses of PRP formulations and tear characteristics.
Results
PRP augmentation significantly improved functional outcomes, with mean differences of 1.82 points (95% CI: 1.13-2.51) for UCLA scores, 2.31 points (95% CI: 1.02-3.61) for Constant scores, and 0.43 points (95% CI: 0.11-0.75) for SST scores (all p < 0.01). VAS pain scores decreased by 0.23 points (95% CI: -0.41 to -0.05, p = 0.01). However, retear rates showed no significant reduction (RR = 0.71, 95% CI: 0.48-1.05, p = 0.09). Benefits were most pronounced in medium/large tears treated with leukocyte-poor PRP and double-row repairs (I 2 = 0-40% for functional outcomes). Conclusion: While PRP enhances early functional recovery and pain control after rotator cuff repair, its capacity to improve structural integrity remains unproven. Clinical implementation requires standardization of PRP protocols and targeted application in patients with larger tears. Future research should investigate optimized biomaterial formulations and personalized treatment strategies.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.3389/fbioe.2025.1665007
- PMID／PMCID
- 41659015 / PMC12877400
- 作者
- Donghua F, Wei L, Di S, Pu Y, Qiang W, Yingchao S, Mingfei S, Xin S
- 首次發表日期
- 2026-01-23Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 13 ／ 期未提供 ／ 1665007
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Donghua F, Wei L, Di S, Pu Y, Qiang W, Yingchao S, Mingfei S, Xin S. Platelet-rich plasma in arthroscopic rotator cuff repair: a meta-analysis of biomaterial efficacy and future directions for personalized sports medicine. Frontiers in bioengineering and biotechnology. 2025;13:1665007. PMID: 41659015. PMCID: PMC12877400. doi:10.3389/fbioe.2025.1665007
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