Frontiers in bioengineering and biotechnology · 2026 · 系統性回顧＋統合分析（依標題推測）
Comparative efficacy of advanced therapeutic modalities for diabetic foot ulcers: a systematic review and meta-analysis including NPWT, stem cells, ESWT, and bioengineered treatments.
踝與足 · 糖尿病足
中文閱讀摘要
系統性回顧與統合分析顯示，NPWT、MSC、ESWT及PRP顯著加速糖尿病足潰瘍癒合，其中NPWT與MSC療效尤著且不良事件較少。
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原始摘要
Background
Diabetic foot ulcers (DFUs) are highly debilitating and often necessitate cutting-edge treatments apart from the usual care. This systematic review and meta-analysis have compared the efficacy of Negative Pressure Wound Therapy (NPWT)/VAC, cell-based therapies (MSC-based therapies), artificial skin, extracorporeal shockwave therapy (ESWT), and platelet-rich plasma (PRP) interventions in promoting healing of difficult wounds, as well as healing by other means.
Methods
The extensive search identified 49 randomized controlled trials. For data analysis, a random-effects model with inverse-variance weighting was used to obtain standardized mean differences (SMDs) with 95% confidence intervals (CIs). The presence of publication bias was determined using funnel plots and Egger's test, while the quality of the studies was assessed by means of Jadad scores and risk of bias tools. GRADE was employed to assess the certainty of the evidence.
Results
Sub-group analysis revealed that NPWT significantly accelerated wound closure compared to standard care SMD of -0.39 (95% CI: 0.57 to -0.21; I 2 = 49%), indicating faster healing times, used days to measure time showed an SMD of -0.94 (95% CI: 1.07 to -0.80; I 2 = 0%) which showed that patients healed at a faster rate. The comparison of different devices and techniques showed an SMD of 0.98 (95% CI: 0.75-1.21; I 2 = 0%), indicating that additional treatments resulted in a greater reduction in wound area. The results were statistically significant because all p-values were lower than 0.05. MSC-based therapies showed similar overall healing (SMD = 0.46, 95% CI: 0.24-0.69) and faster closure (SMD = -1.04, 95% CI: 1.28 to -0.8). Additionally, trials of bioengineered skin substitutes, ESWT, and PRP all showed statistically significant improvements in time to wound closure and overall healing. Relative to the control group, adverse events were fewer in the NPWT and PRP groups (SMD = -0.24, 95% CI: 0.42 to -0.05).
Conclusion
The NPWT and MSC-based therapy, in particular, represent major improvements in healing outcomes for diabetic foot ulcers (DFUs) and in the speed of closure compared with standard treatment.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.3389/fbioe.2026.1792670
- PMID／PMCID
- 42137620 / PMC13167936
- 作者
- Guan X, Zhu G, Jiang H, Wang B, Cheng J
- 首次發表日期
- 2026-04-29Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 14 ／ 期未提供 ／ 1792670
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Guan X, Zhu G, Jiang H, Wang B, Cheng J. Comparative efficacy of advanced therapeutic modalities for diabetic foot ulcers: a systematic review and meta-analysis including NPWT, stem cells, ESWT, and bioengineered treatments. Frontiers in bioengineering and biotechnology. 2026;14:1792670. PMID: 42137620. PMCID: PMC13167936. doi:10.3389/fbioe.2026.1792670
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