Frontiers in endocrinology · 2026 · 系統性回顧＋統合分析（依標題推測）

Effects of autologous platelet-rich plasma in recurrent implantation failure: a systematic review and meta-analysis.

注射・再生・儀器治療 · 富血小板血漿治療

中文閱讀摘要

統合分析顯示RIF患者使用PRP提升妊娠率，但早產風險顯著增加，且效果因胚胎階段與失敗次數而異。

AI 依來源摘要整理，未經人工逐篇核對。閱讀結論前，請回溯研究族群、方法與限制。

原始摘要

Objective

The role of intrauterine PRP infusion in managing recurrent implantation failure (RIF) remains controversial despite its emerging clinical use. This systematic review aims to evaluate its therapeutic potential in RIF patients and further to investigate variations in outcomes based on transfer cycle type, embryo developmental stage, RIF diagnostic criteria, and endometrial thickness.

Methods

We systematically searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, Scopus, and Web of Science for randomized controlled trials (RCTs) investigating PRP treatment for RIF patients from the beginning of the database to May 2025.

Results

This meta-analysis showed that PRP administration significantly improved clinical pregnancy rate (CPR) [OR = 3.18, 95%CI (2.45, 4.14), I 2 = 3%], biochemical pregnancy rate (BPR) [OR = 2.84, 95%CI (2.22, 3.63), I 2 = 0%], ongoing pregnancy rate (OPR) [OR = 3.41, 95%CI (2.08, 5.60), I 2 = 30%] and live birth rate (LBR) [OR=5.10, 95%CI (1.95, 13.37), I 2 = 75%] in women with RIF. However, PRP intrauterine infusion did not reduce miscarriage rate (MR). Notably, the preterm birth rate was significantly higher in the PRP group compared to controls [OR = 8.24, 95%CI (2.09, 32.41), I 2 = 0%]. Subgroup analysis demonstrated that PRP improved CPR, BPR and LBR in both the fresh and frozen embryo transfer cycles. Additionally, while PRP increased CPR, LBR and reduced MR in blastocyst transfers [CPR OR = 3.84, 95%CI (2.82, 5.23), I 2 = 0%; LBR OR = 7.32, 95%CI (3.17, 16.90), I 2 = 63%; MR OR = 0.27, 95%CI (0.07, 0.96), I 2 = 54%], these effects were not observed in cleavage-stage embryo transfers. Moreover, PRP administration associated with a higher CPR [OR = 3.84, 95%CI (2.82, 5.23), I 2 = 0%], OPR[OR = 4.13, 95%CI (1.79, 9.56), I 2 = 48%], LBR [OR = 7.32, 95%CI (3.17, 16.90), I 2 = 63%] and a lower MR [OR = 0.27, 95%CI (0.07, 0.96), I 2 = 54%] in women with ≥3 prior implantation failure, it did not confer the same benefit to those with a history of ≥2 failed cycles.

Conclusion

These findings suggest a possible beneficial role for PRP on pregnancy outcomes to some extent in women with RIF, particularly in cases with ≥3 prior failed transfers, and blastocyst transfer may increase LBR and reduce miscarriage risk. However, further investigation is warranted to determine whether this treatment may pose an increased risk of preterm birth.

Systematic review registration

https://www.crd.york.ac.uk/prospero/, identifier CRD420251061511.

至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19

書目、來源與全文狀態

DOI: 10.3389/fendo.2026.1730259
PMID／PMCID: 42058785 / PMC13120909
作者: Pan Z, Guo X, Su Q, Ye H
首次發表日期: 2026-04-14Europe PMC 提供，部分日期可能依年份或月份推定。
卷／期／頁碼或文章編號: 17 ／期未提供／ 1730259
書目來源與查核日期: Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
全文與授權: 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。來源授權標示：cc by。

可回溯引用

Pan Z, Guo X, Su Q, Ye H. Effects of autologous platelet-rich plasma in recurrent implantation failure: a systematic review and meta-analysis. Frontiers in endocrinology. 2026;17:1730259. PMID: 42058785. PMCID: PMC13120909. doi:10.3389/fendo.2026.1730259

原始文獻 ↗來源列出的免費全文 ↗

本站供教育與研究參考。單篇摘要、文體標籤與期刊影響係數不等於證據品質或個別病人的診療建議。