Frontiers in endocrinology · 2026 · 系統性回顧（依標題推測）
Systematic review of the efficacy and safety of biologically and tissue-derived therapies for the treatment of diabetic foot.
踝與足 · 糖尿病足
中文閱讀摘要
系統性回顧顯示自體細胞治療顯著提升糖尿病足潰瘍癒合率、縮短癒合時間，且安全性良好。
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原始摘要
Background
Diabetic foot ulcers are a common and serious complication in diabetic patients, and traditional treatments have limited healing rates. Autologous cells and related products, as an emerging therapy, require systematic evaluation for their efficacy and safety.
Objective
To systematically evaluate and meta-analyze the efficacy and safety of autologous cells and related products in the treatment of diabetic foot ulcers.
Methods
Relevant randomized controlled trials up to November 2025 were searched in PubMed and Embase databases. Patients with diabetic foot ulcers were included, and the intervention was autologous cell therapy. Data on healing rate, percentage reduction in ulcer area, and healing days were extracted and meta-analyzed using RevMan 5.3.
Results
A total of 26 randomized controlled trials (RCTs) involving 2,214 patients were included. The autologous cell therapy group showed a significantly higher rate of complete healing than the control group (RR = 0.54, 95% CI: 0.45). The difference in ulcer area reduction was significantly greater (MD = 24.6%, 95%CI: 18.3-30.9, P<0.001) and healing time was significantly shorter (MD= -48.8 days, 95% CI: -74.19 to -23.48, P = 0.0002). There were no significant differences in adverse events such as amputation and mortality between the two groups. In conclusion, autologous cell therapy can significantly improve the healing rate and accelerate ulcer healing in diabetic foot ulcers, with good safety, making it a promising treatment option.
Systematic review registration
https://www.crd.york.ac.uk/prospero/, identifier CRD420261293843.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.3389/fendo.2026.1800592
- PMID／PMCID
- 42022905 / PMC13095566
- 作者
- Teng J, Lin F, Wang L, Jiang M, Li Z, Yan G, Mi J
- 首次發表日期
- 2026-04-07Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 17 ／ 期未提供 ／ 1800592
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Teng J, Lin F, Wang L, Jiang M, Li Z, Yan G, Mi J. Systematic review of the efficacy and safety of biologically and tissue-derived therapies for the treatment of diabetic foot. Frontiers in endocrinology. 2026;17:1800592. PMID: 42022905. PMCID: PMC13095566. doi:10.3389/fendo.2026.1800592
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