Frontiers in endocrinology · 2026 · 統合分析（依標題推測）
A network meta-analysis of the effects of different aerobic exercise prescriptions on bone density in osteoporosis patients.
高齡・肌少・骨骼健康 · 骨質疏鬆症
中文閱讀摘要
網路統合分析顯示，高強度、每週4-5次、每次30-59分鐘、持續24週的有氧運動，對骨質疏鬆患者骨密度改善效果最佳。
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原始摘要
Objective
To compare the effects of different doses of aerobic exercise on bone mineral density in osteoporosis patients through a network meta-analysis.
Methods
This study systematically retrieved and screened 7 databases (including PubMed, Web of Science, and Cochrane Library, etc.) for randomized controlled trials on aerobic exercise interventions for osteoporosis patients from database inception to June 2025. The study strictly followed the PRISMA guidelines, within the framework of frequency theory, we conducted a network meta-analysis using Stata 15.0 software, quality assessment of the literature using Cochrane bias risk assessment tool.
Results
A total of 27 randomized controlled trials involving 2,183 participants were included in this study. The network meta-analysis revealed that aerobic exercise regimens with the following parameter: intensity (High, medium, low-to-medium and medium-to-high intensity progressive loads), training duration (24 weeks), single-session duration (30-59min), and intervention frequency (2-3, 4-5times a week) all significantly improved bone density in osteoporosis patients compared to the control group. Indirect comparison results revealed statistically significant advantages of high-intensity exercise over moderate and low-intensity exercise. The frequency of 4-5 times a week showed a significant advantage compared to 2-3 times and 6-7 times per week. No significant differences were observed between intervention frequency and duration. The Surface Under the Cumulative Ranking Curve (SUCRA) demonstrated the following rankings: the efficacy was highest at the high intensity level, followed by the medium to high intensity level, then the low to medium intensity, the medium intensity, the Low intensity level, and the control group. For exercise duration, a 24-week intervention achieved the best efficacy, followed by a 12-week intervention, then the 48 weeks or longer, and the control group. Regarding single session intervention time, sessions lasting 30 to 59 minutes produced superior efficacy, followed by 60 minutes or longer, then the control group. In terms of weekly exercise frequency, training 4 to 5 times per week ranked first in efficacy, followed by 2 to 3 times per week, then 6 to 7 times per week, and the control group.
Conclusion
The results showed that the optimal exercise dose for improving bone mineral density (BMD) in OP patients was aerobic exercise with high intensity, 30-59min per session, 4-5 times per week, and continue 24 weeks.
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO/view/CRD420251155131, identifier CRD420251155131.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.3389/fendo.2026.1828031
- PMID／PMCID
- 42318219 / PMC13271876
- 作者
- Zhou X, Yang N, Xi C, Ji J, Xu T
- 首次發表日期
- 2026-06-03Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 17 ／ 期未提供 ／ 1828031
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Zhou X, Yang N, Xi C, Ji J, Xu T. A network meta-analysis of the effects of different aerobic exercise prescriptions on bone density in osteoporosis patients. Frontiers in endocrinology. 2026;17:1828031. PMID: 42318219. PMCID: PMC13271876. doi:10.3389/fendo.2026.1828031
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