Frontiers in immunology · 2026 · 系統性回顧＋統合分析（依標題推測）
Effects of exercise interventions on inflammatory biomarker levels in older adults with frailty and/or sarcopenia: a systematic review and meta-analysis.
高齡・肌少・骨骼健康 · 肌少症
中文閱讀摘要
統合分析顯示，運動介入顯著降低衰弱或肌少症長者TNF-α，但對IL-6及CRP無顯著改善。
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原始摘要
Objective
Excessive secretion of inflammatory biomarkers exerts adverse effects on muscle strength and function, and is associated with the development and progression of sarcopenia and frailty. For the improvement of inflammatory biomarker concentrations, given the remaining limitations of current pharmacological and nutritional therapies, exercise intervention may serve as a potential non-pharmacological intervention. The purpose of this study is to systematically evaluate the effects of exercise interventions on serum inflammatory biomarker levels in older adults with frailty and/or sarcopenia by employing a meta-analysis approach.
Methods
A systematic search was conducted in PubMed, Web of Science, Cochrane Library, EMBASE, and Scopus (from database inception to October 2025) to identify randomized controlled trials (RCTs) investigating the impact of exercise interventions on serum inflammatory biomarker levels in older adults with frailty and/or sarcopenia. Data were analyzed using RevMan 5.4 and Stata 15.1. A random-effects model was employed to calculate standardized mean differences (SMD) and 95% confidence intervals (95% CI). The study protocol was registered with PROSPERO (CRD420251160555).
Results
A total of 21 studies (comprising 26 RCTs) were included, involving 1,297 participants (intervention group: 659; control group: 613) with an age range of 63.6 to 86.7 years.Meta-analysis results revealed that exercise interventions did not significantly improve serum interleukin-6 (IL-6) (SMD = -0.04, 95% CI: -0.17 to 0.09, p = 0.52, I² = 10%) or C-reactive protein (CRP) concentrations (SMD = -0.08, 95% CI: -0.25 to 0.08, p = 0.32, I² = 0%) in older adults with sarcopenia and/or frailty. However, exercise interventions exerted a significant improving effect on tumor necrosis factor-α (TNF-α) (SMD = -0.31, 95% CI: -0.44 to -0.18, p < 0.0001, I² = 37%).
Conclusion
Exercise interventions significantly improve TNF-α concentrations but do not exert a significant improving effect on IL-6 or CRP in older adults with frailty and/or sarcopenia. These findings may provide key evidence-based support for clinical non-pharmacological interventions.
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO/view/CRD420251160555, identifier CRD420251160555.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.3389/fimmu.2026.1734359
- PMID／PMCID
- 42148069 / PMC13171393
- 作者
- Chu R, Xie Y, Li W, Du Y, Ni T, Tu X, Xu B, Zhao J
- 首次發表日期
- 2026-04-30Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 17 ／ 期未提供 ／ 1734359
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Chu R, Xie Y, Li W, Du Y, Ni T, Tu X, Xu B, Zhao J. Effects of exercise interventions on inflammatory biomarker levels in older adults with frailty and/or sarcopenia: a systematic review and meta-analysis. Frontiers in immunology. 2026;17:1734359. PMID: 42148069. PMCID: PMC13171393. doi:10.3389/fimmu.2026.1734359
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