Frontiers in medicine · 2026 · 系統性回顧＋統合分析（依標題推測）
Therapeutic efficacy and safety of injectable platelet-rich plasma in women with stress urinary incontinence: a systematic review and meta-analysis.
髖與鼠蹊 · 應力性尿失禁
中文閱讀摘要
統合分析顯示女性壓力性尿失禁注射PRP短期改善症狀、尿動力學及生活品質，不良反應輕微，但需更多RCT驗證持久性。
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原始摘要
Background
Stress urinary incontinence (SUI) is a prevalent pelvic floor disorder with significant effects on women's quality of life. While surgical and non-surgical interventions exist, limitations underscore the need for alternative therapies. Injectable platelet-rich plasma (PRP) has emerged as a regenerative approach targeting tissue restoration. This study aimed to systematically evaluate the efficacy and safety of PRP injections for female SUI.
Methods
This systematic review and meta-analysis adhered to the PRISMA guidelines. Comprehensive searches of PubMed, Scopus, and Cochrane Library up to April 2025 identified randomized controlled trials (RCTs) and quasi-experimental studies assessing PRP for SUI. The review protocol was prospectively registered in the International Prospective Register of Systematic Reviews (CRD420251118485). Eligible studies reported outcomes on symptom severity, urodynamic parameters, quality of life, or adverse events. Risk of bias was assessed using Cochrane RoB 2.0 for RCTs and the NHLBI tool for before-and-after studies. Pooled effect sizes were calculated using random- or fixed-effects models as appropriate.
Results
Eight studies (three RCTs and five quasi-experimental; n = 257) were included. PRP significantly improved symptom severity, with pooled reductions in UDI-6 and ICIQ-SF scores at 1-3 months. Urodynamic analysis revealed significant increases in abdominal leak point pressure (MD = 51.07; 95% CI: 36.21-65.93; p < 0.0001), while functional profile length remained unchanged. Quality-of-life scores (IIQ-7, ICIQ-SF) showed consistent improvement. Reported adverse events were mild and self-limiting, with no serious complications observed.
Conclusion
Injectable PRP demonstrates promising short-term efficacy in reducing symptoms, improving urodynamic function, and enhancing quality of life in women with SUI, with a favorable safety profile. Larger, standardized RCTs with longer follow-up are needed to validate durability and define its role relative to established therapies.
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO/view/CRD420251118485, CRD420251118485.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.3389/fmed.2026.1728478
- PMID／PMCID
- 41930120 / PMC13038994
- 作者
- Utama BI, Birru ABA, Cuandra KN, Puspita R, Arianto S, Pranowo GY, Saifana Q, Gandhy MAK, Puteri KJ, Mifindra R, Husodho GVP, Alexander RF, Yuliani M, NurCita B, Tristan CD
- 首次發表日期
- 2026-03-18Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 13 ／ 期未提供 ／ 1728478
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Utama BI, Birru ABA, Cuandra KN, Puspita R, Arianto S, Pranowo GY, Saifana Q, Gandhy MAK, Puteri KJ, Mifindra R, Husodho GVP, Alexander RF, Yuliani M, NurCita B, Tristan CD. Therapeutic efficacy and safety of injectable platelet-rich plasma in women with stress urinary incontinence: a systematic review and meta-analysis. Frontiers in medicine. 2026;13:1728478. PMID: 41930120. PMCID: PMC13038994. doi:10.3389/fmed.2026.1728478
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