Frontiers in medicine · 2026 · 系統性回顧（依標題推測）
Intra-articular adipose-derived cell therapies for knee osteoarthritis: a systematic review of randomized controlled trials.
膝 · 膝骨關節炎
中文閱讀摘要
脂肪衍生細胞療法對膝關節退化性關節炎有效。
原始摘要
Introduction
Knee osteoarthritis is a leading cause of chronic pain, functional limitation, and disability worldwide, imposing a substantial socioeconomic burden. Despite advances in conservative management and intra-articular therapies, many patients experience limited or transient symptomatic relief, underscoring the need for biologically based interventions. Intra-articular adipose-derived cell therapies, including adipose-derived mesenchymal stem or stromal cells (ADSCs), stromal vascular fraction (SVF), and microfragmented adipose tissue (MFAT), have emerged as regenerative strategies aimed at modulating inflammation and joint homeostasis. This systematic review evaluated the efficacy, structural effects, and safety of intra-articular adipose-derived cell-based therapies for knee osteoarthritis in adults.
Methods
Randomized controlled trials published between 2015 and 2025 were identified through systematic searches of PubMed, Embase, Scopus, and Web of Science. Eligible studies compared ADSCs, SVF, or MFAT with placebo, hyaluronic acid, platelet-rich plasma, corticosteroids, or conservative care, and reported outcomes on pain, function, imaging-based structural changes, and safety.
Results
Nineteen randomized controlled trials met inclusion criteria. Across studies, adipose-derived interventions, particularly ADSC-based therapies, produced clinically meaningful reductions in pain and improvements in functional outcomes assessed by WOMAC, KOOS, and visual analog scales.
Discussion
Several ADSC and SVF trials reported favorable magnetic resonance imaging findings, including improvements in cartilage quality, although consistent cartilage regeneration was not demonstrated. MFAT trials yielded heterogeneous results, often showing symptomatic benefits comparable to established injective therapies but limited structural effects. No serious treatment-related adverse events were reported. Intra-articular adipose-derived cell therapies are safe and provide meaningful pain relief and functional improvement in selected patients, with ADSCs showing the most consistent clinical signals.
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO/view/CRD420251241498, Identifier: CRD420251241498.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.3389/fmed.2026.1771008
- PMID／PMCID
- 42100287 / PMC13147480
- 作者
- Batista JD, Silva LD, Batista JD, Pereira GS, da Silva ML
- 首次發表日期
- 2026-04-22Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 13 ／ 期未提供 ／ 1771008
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Batista JD, Silva LD, Batista JD, Pereira GS, da Silva ML. Intra-articular adipose-derived cell therapies for knee osteoarthritis: a systematic review of randomized controlled trials. Frontiers in medicine. 2026;13:1771008. PMID: 42100287. PMCID: PMC13147480. doi:10.3389/fmed.2026.1771008
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