Frontiers in pharmacology · 2026 · 系統性回顧＋統合分析（依標題推測）
Effects of cognitive-motor interventions on serum BDNF levels in adults and older population post-stroke: a systematic review and meta-analysis of randomized controlled trials.
神經系統疾病復健 · 腦中風
中文閱讀摘要
系統性回顧與統合分析顯示，腦中風後認知-運動介入顯著提升血清BDNF，但異質性極高，解讀需謹慎。
AI 依來源摘要整理，未經人工逐篇核對。閱讀結論前，請回溯研究族群、方法與限制。
原始摘要
Introduction
Cognitive-motor interventions have emerged as promising rehabilitation strategies to enhance neuroplasticity following stroke; however, their effects on circulating brain-derived neurotrophic factor (BDNF) remain incompletely understood. This systematic review and meta-analysis aimed to quantify the effects of cognitive-motor interventions on serum BDNF levels in adults and older adults after stroke.
Methods
A comprehensive literature search of MEDLINE/PubMed, Scopus, Cochrane, Web of Science (Core Collection), EBSCOhost, CINAHL, and ProQuest was conducted through December 2025. Randomized controlled trials evaluating cognitive-motor interventions and reporting serum brain-derived neurotrophic factor outcomes in post-stroke populations were included. Methodological quality and certainty of evidence were assessed according to PRISMA 2020 guidelines, the Oxford Centre for Evidence-Based Medicine framework, the RoB two tool, and GRADEpro. The review protocol was registered in PROSPERO (CRD420251140852).
Results
Nine randomized controlled trials involving 457 participants met the inclusion criteria. Meta-analysis demonstrated that cognitive-motor interventions elicited a statistically significant increase in serum BDNF levels compared with control conditions (Hedges' g = 2.51; 95% CI: 0.97 to 4.06; p = 0.001; I 2 = 92%), indicating a large overall effect.
Conclusion
These findings suggest that cognitive-motor interventions may increase circulating BDNF levels after stroke, supporting their potential role in promoting neuroplastic mechanisms during rehabilitation; however, the very high heterogeneity across studies warrants cautious interpretation.
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO/view/CRD420251140852 identifer, PROSPERO 2025 CRD420251140852.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.3389/fphar.2026.1835358
- PMID／PMCID
- 42181896 / PMC13190536
- 作者
- Vásquez-Carrasco E, Albornoz-Gómez V, Cerda-González E, González-Guerra C, Salazar-Díaz J, Hernandez-Martinez J, Sandoval-Vásquez C, Valdés-Badilla P
- 首次發表日期
- 2026-05-07Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 17 ／ 期未提供 ／ 1835358
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Vásquez-Carrasco E, Albornoz-Gómez V, Cerda-González E, González-Guerra C, Salazar-Díaz J, Hernandez-Martinez J, Sandoval-Vásquez C, Valdés-Badilla P. Effects of cognitive-motor interventions on serum BDNF levels in adults and older population post-stroke: a systematic review and meta-analysis of randomized controlled trials. Frontiers in pharmacology. 2026;17:1835358. PMID: 42181896. PMCID: PMC13190536. doi:10.3389/fphar.2026.1835358
本站供教育與研究參考。單篇摘要、文體標籤與期刊影響係數不等於證據品質或個別病人的診療建議。