Frontiers in physiology · 2026 · 系統性回顧＋統合分析（依標題推測）

Effects of blood flow restriction exercise interventions on patellofemoral pain syndrome: a systematic review and meta-analysis.

膝 · 髕股疼痛症候群

中文閱讀摘要

統合分析顯示，BFRT較一般復健能短期減痛並微幅提升伸膝肌力，但對自評膝功能及股四頭肌形態無顯著優勢，且證據有限。

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原始摘要

Purpose

Previous studies suggest that blood flow restriction training (BFRT) may improve pain and knee function in individuals with patellofemoral pain syndrome (PFPS); however, its additional clinical benefit compared with general rehabilitation exercise (GRE) remains uncertain. This study aimed to compare the effects of BFRT and GRE in PFPS rehabilitation through a systematic review and meta-analysis.

Methods

The Cochrane Library, PubMed, Web of Science, PEDro, Scopus, and ScienceDirect were searched up to February 14, 2026 (CRD420261296172). Interventional studies comparing BFRT with GRE in exercise-based rehabilitation for PFPS were included. Outcomes included pain intensity, self-reported knee function, knee extensor strength, and quadriceps morphology.

Results

Thirteen studies were included qualitatively, and 11 randomized controlled trials involving 508 participants were included in the meta-analysis. BFRT produced immediate reductions in pain during functional tasks, including shallow single-leg squat (MD = 2.13; P < 0.00001), deep single-leg squat (MD = 2.38; P < 0.00001), and step-down tasks (MD = 2.05; P < 0.00001). This short-term analgesic effect remained significant 45 minutes after exercise. Over longer-term follow-up, BFRT showed a modest benefit for overall pain (SMD = 0.37; P = 0.0005) and knee extensor strength (SMD = 0.28; P = 0.01) compared with GRE. However, self-reported knee function did not differ significantly between groups (MD = 1.93; P = 0.12). Evidence for quadriceps morphology was limited, and no clear between-group difference was observed (SMD = 0.30; P = 0.24).

Conclusion

In PFPS rehabilitation, BFRT may provide clinically relevant benefits for short-term pain reduction during functional tasks and modest improvements in knee extensor strength. However, current evidence does not show a clear advantage for self-reported knee function or quadriceps morphological outcomes. These findings should be interpreted cautiously because of protocol heterogeneity and limited long-term evidence. Systematic review registration : https://www.crd.york.ac.uk/PROSPERO/view/CRD420261296172, identifier CRD420261296172.

至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19

書目、來源與全文狀態

DOI: 10.3389/fphys.2026.1859305
PMID／PMCID: 42394841 / PMC13322932
作者: Hou C, Liu Z, Wang C, Wang J, Zhou H, Ma X, Huang S, Tao J, Xiong Z
首次發表日期: 2026-06-18Europe PMC 提供，部分日期可能依年份或月份推定。
卷／期／頁碼或文章編號: 17 ／期未提供／ 1859305
書目來源與查核日期: Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
全文與授權: 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。來源授權標示：cc by。

可回溯引用

Hou C, Liu Z, Wang C, Wang J, Zhou H, Ma X, Huang S, Tao J, Xiong Z. Effects of blood flow restriction exercise interventions on patellofemoral pain syndrome: a systematic review and meta-analysis. Frontiers in physiology. 2026;17:1859305. PMID: 42394841. PMCID: PMC13322932. doi:10.3389/fphys.2026.1859305

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