Frontiers in sports and active living · 2026 · 系統性回顧（依標題推測）

Effects of exercise training on skeletal muscle function in patients with mitochondrial myopathy: a systematic review

神經系統疾病復健 · 粒線體肌病變

中文閱讀摘要

系統性回顧顯示，中強度有氧與阻力訓練可改善線粒體肌病患者的肌力與功能，但對不同基因型反應不一，需更多試驗確認長期效益。

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原始摘要

Background

Mitochondrial myopathy (MM) is a group of rare, progressive muscle disorders characterized by impaired oxidative phosphorylation due to mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) mutations, leading to exercise intolerance, muscle weakness, and metabolic dysfunction. Although exercise is increasingly recognized for its capacity to enhance mitochondrial function and muscle performance, the specific effects of different exercise prescriptions (in terms of modality, intensity, and duration) on MM and their phenotype-specific outcomes remain heterogeneous. This study systematically investigates how various exercise types influence mitochondrial function, muscle performance, and clinical outcomes across MM subtypes.

Methods

Databases including PubMed, Web of Science, Embase, and Scopus were searched from 1990 to September 2025. Clinical trials involving exercise interventions in MM patients were included, with outcomes covering exercise capacity, muscle function, mitochondrial markers, and metabolic indices. Risk of bias was assessed using Revised Cochrane Risk-of-Bias Tool for Randomized Trials (RoB 2) and Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I V2), and methodological quality was appraised with the Mixed Methods Appraisal Tool (MMAT).

Results

Fifteen studies (1 randomized controlled trial and 14 non-randomized trials) including a total of 157 MM patients (sample size per study: 4-20) were analyzed. Moderate-intensity aerobic and resistance exercise consistently improved maximal oxygen uptake (VO 2 max), maximal workload (W max), muscle strength, and mitochondrial enzyme activity, with no consistent group-level increases observed in creatine kinase (CK) levels or mtDNA mutation burden. Aerobic training enhanced oxidative capacity, phosphocreatine (PCr) recovery, and antioxidant defense, while resistance training improved muscle strength, satellite cell activation, and reduced cytochrome c oxidase (COX)-deficient fibers. Combined regimens yielded additive benefits. Most interventions lasted 8-14 weeks, 3-5 sessions per week. Phenotype-specific responses were evident: patients with large-scale deletions or m.3243A>G mutations showed favorable adaptation, whereas other point mutations or microdeletions displayed variable or adverse responses.

Conclusion

Moderate-intensity, phenotype-specific exercise prescriptions, especially those integrating both aerobic and resistance components, may enhance mitochondrial and muscular function in patients with mitochondrial myopathy while reducing the likelihood of adverse effects. However, larger controlled trials are needed to confirm long-term efficacy and to clarify potential risk profiles.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/view/CRD420251145502, PROSPERO CRD420251145502.

至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19

書目、來源與全文狀態

DOI: 10.3389/fspor.2026.1710264
PMID／PMCID: 42040635 / PMC13102759
作者: Wan Q, Ding Y, Liu W, Yang K
首次發表日期: 2026-04-09Europe PMC 提供，部分日期可能依年份或月份推定。
卷／期／頁碼或文章編號: 8 ／期未提供／ 1710264
書目來源與查核日期: Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
全文與授權: 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。來源授權標示：cc by。

可回溯引用

Wan Q, Ding Y, Liu W, Yang K. Effects of exercise training on skeletal muscle function in patients with mitochondrial myopathy: a systematic review. Frontiers in sports and active living. 2026;8:1710264. PMID: 42040635. PMCID: PMC13102759. doi:10.3389/fspor.2026.1710264

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