Frontiers in sports and active living · 2026 · 系統性回顧＋統合分析（依標題推測）

Effects of exercise on cardiorespiratory fitness in individuals with MASLD: a systematic review and dose-response meta-analysis

代謝・營養・內分泌 · 代謝功能障礙相關脂肪肝病

中文閱讀摘要

系統性回顧與統合分析顯示，MASLD患者運動顯著提升CRF，劑量反應分析提示非線性關聯，但峰值僅為模型指標，非確定處方閾值。

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原始摘要

Background

Cardiorespiratory fitness (CRF), primarily assessed via maximal oxygen uptake (VO₂max) or peak oxygen uptake (VO₂peak) during incremental exercise testing, is a robust predictor of cardiovascular mortality in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). However, the exercise volume associated with greater CRF gains in this population remains poorly defined. Therefore, this study aimed to evaluate the efficacy of supervised structured exercise on CRF in MASLD individuals and characterize the dose-response relationship using restricted cubic splines.

Methods

We systematically searched PubMed, Embase, and Web of Science through July 18, 2025, for randomized controlled trials comparing supervised exercise with usual care in adults with MASLD. The primary outcome was CRF, measured as VO 2 peak/VO 2 max. Standardized mean differences (SMDs) were pooled using random-effects models. Dose-response analysis was conducted via a Bayesian framework using restricted cubic spline model to identify optimal weekly and cumulative exercise volumes.

Results

Thirteen RCTs comprising 15 exercise-control comparisons involving 356 participants were included. Exercise significantly improved CRF compared with control conditions (SMD = 0.82, 95% CI: 0.54-1.10; I 2 = 30.1%). In the MD-based analysis restricted to studies reporting CRF in mL/kg/min, exercise increased CRF by 3.52 mL/kg/min (95% CI: 2.04-5.01; I 2 = 65.5%). Exploratory dose-response analyses suggested non-linear associations, with estimated peak points of approximately 590 MET-min/week for weekly exercise volume and 10,715 MET-min for total cumulative exercise volume.

Conclusion

Exercise interventions improve CRF in individuals with MASLD. Exploratory dose-response analyses suggest that CRF gains may follow a non-linear pattern with increasing exercise volume, but the estimated peak points should be interpreted as model-based indicators rather than definitive prescription thresholds.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/view/CRD420251243283, PROSPERO CRD420251243283.

至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19

書目、來源與全文狀態

DOI: 10.3389/fspor.2026.1854220
PMID／PMCID: 42404333 / PMC13330729
作者: Huang W, He Y, Lu H, Wang J, Liang Y, Zeng L, Li L, Lu H, Li Z, Wang Z, Xie Y, Duan P, Lu J
首次發表日期: 2026-06-19Europe PMC 提供，部分日期可能依年份或月份推定。
卷／期／頁碼或文章編號: 8 ／期未提供／ 1854220
書目來源與查核日期: Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
全文與授權: 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。來源授權標示：cc by。

可回溯引用

Huang W, He Y, Lu H, Wang J, Liang Y, Zeng L, Li L, Lu H, Li Z, Wang Z, Xie Y, Duan P, Lu J. Effects of exercise on cardiorespiratory fitness in individuals with MASLD: a systematic review and dose-response meta-analysis. Frontiers in sports and active living. 2026;8:1854220. PMID: 42404333. PMCID: PMC13330729. doi:10.3389/fspor.2026.1854220

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