Frontiers in surgery · 2026 · 統合分析（依標題推測）
The efficacy and safety of platelet rich plasma and hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis.
膝 · 膝骨關節炎
中文閱讀摘要
統合分析顯示，膝骨關節炎患者接受PRP注射較HA在WOMAC、VAS及IKDC分數上顯著改善，但兩組不良事件發生率無顯著差異，安全性相當。
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原始摘要
Purpose
To investigate the efficacy and safety of intra-articular injection ratio of platelet rich plasma (PRP) and hyaluronic acid (HA), and provide evidence-based strategies for the treatment of knee osteoarthritis (KOA).
Methods
Search PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases to retrieve literature published from the beginning of database establishment to October 2024. Include in published randomized controlled trials (RCTs) or cohort studies. The research subjects are KOA patients, with the experimental group receiving intra-articular injection of PRP and the control group receiving intra-articular injection of HA. Quality evaluation of the inclusion of Cochrane Handbook risk assessment tools using RevMan5 Perform meta-analysis on outcome measures using three software.
Results
18 articles were included, with a total of 1,326 patients. PRP showed significantly better WOMAC scores at 6 months (SMD=-8.32, P < 0.0001) and 12 months (SMD=-3.15, P < 0.0001), superior IKDC scores at 6 months (SMD=0.85, P = 0.004), and greater pain reduction on VAS at 3 months (SMD=-0.56, P < 0.0001) and 6 months (SMD=-0.85, P < 0.0001). EQ-VAS scores also favored PRP at 2 months (SMD=0.20, P = 0.04) and 12 months (SMD=0.35, P = 0.001). No significant differences were found in adverse events (OR = 1.31, P = 0.21) or patient satisfaction (MD = 1.60, P = 0.08), indicating comparable safety profiles.
Conclusion
PRP has a good clinical therapeutic effect on KOA. Based on this meta-analysis, compared with simple intra-articular injection of HA, PRP can improve WOMAC score, VAS score, and IKDC index score after 6 months of treatment, and enhance patients' health status. In terms of the incidence of adverse events, the safety of the two treatment options is similar.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.3389/fsurg.2026.1725534
- PMID／PMCID
- 41890142 / PMC13013302
- 作者
- An F, Wu H, Wang J, Zhang G, Yan K, Wu F, Wang J, Zhang H
- 首次發表日期
- 2026-03-11Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 13 ／ 期未提供 ／ 1725534
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
An F, Wu H, Wang J, Zhang G, Yan K, Wu F, Wang J, Zhang H. The efficacy and safety of platelet rich plasma and hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. Frontiers in surgery. 2026;13:1725534. PMID: 41890142. PMCID: PMC13013302. doi:10.3389/fsurg.2026.1725534
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