Journal of global health · 2026 · 系統性回顧＋統合分析（依標題推測）
Habitual physical activity and sarcopenia: a systematic review and meta-analysis of prospective cohort studies.
高齡・肌少・骨骼健康 · 肌少症
中文閱讀摘要
統合分析顯示中高量常規體活動顯著降低肌少症風險，但測量異質性大，需進一步研究釐清最佳劑量。
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原始摘要
Background
Habitual physical activity (HPA) has been associated with a lower risk of sarcopenia by enhancing skeletal muscle protein synthesis and suppressing systemic inflammation. However, the evidence for a long-term protective association remains inconclusive. Therefore, we conducted a systematic review and meta-analysis to quantify the association between HPA and sarcopenia.
Methods
We searched PubMed, the Cochrane Library, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Web of Science, and the China National Knowledge Infrastructure for prospective cohort studies on the relationship between physical activity (PA) and sarcopenia. We selected English and Chinese-language literature published before 6 October 2025, and assessed study quality using the Newcastle-Ottawa Scale. Data were statistically synthesised by calculating pooled relative risks (RRs) and 95% confidence intervals (CIs) using a random-effects model with the generic inverse-variance method.
Results
This meta-analysis included nine prospective cohort studies involving 21 265 participants. High levels of HPA were associated with a significantly lower risk of sarcopenia compared to the low levels (RR = 0.55; 95% CI = 0.44-0.67). This protective association remained consistent in subgroup analyses stratified by gender and by compliance with international PA guidelines. Furthermore, moderate HPA was also associated with a reduced risk compared to low HPA levels (RR = 0.73; 95% CI = 0.50-0.96).
Conclusions
Our analysis indicates that moderate to high levels of HPA are independently associated with a lower risk of sarcopenia, serving as a significant protective factor. However, given the methodological heterogeneity in PA measurement, further high-quality prospective studies are needed to clarify the optimal PA dose while accounting for potential reverse causality.
Registration
PROSPERO: CRD420251162529.
至 Europe PMC 閱讀完整來源 ↗ · 擷取日期 2026-10-19
書目、來源與全文狀態
- DOI
- 10.7189/jogh.16.04095
- PMID／PMCID
- 42359826 / PMC13307538
- 作者
- Dai D, Xie F, Cui J, Wang S, Cai J, Wang G, Yao F
- 首次發表日期
- 2026-06-26Europe PMC 提供，部分日期可能依年份或月份推定。
- 卷／期／頁碼或文章編號
- 16 ／ 期未提供 ／ 04095
- 書目來源與查核日期
- Europe PMC · 2026-10-19僅核對書目欄位與來源連結；不代表已評讀研究品質。
- 全文與授權
- 來源列有免費全文（查核 2026-10-19），未逐篇測試 PDF 下載。 來源授權標示：cc by。
可回溯引用
Dai D, Xie F, Cui J, Wang S, Cai J, Wang G, Yao F. Habitual physical activity and sarcopenia: a systematic review and meta-analysis of prospective cohort studies. Journal of global health. 2026;16:04095. PMID: 42359826. PMCID: PMC13307538. doi:10.7189/jogh.16.04095
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